A remake of Duke Nukem 3D, made by dedicated fans, is on its way. It's been named Duke Nukem: Next-Gen, is made with the Unreal 3 engine and Gearbox - who are developing Duke Nukem Forever - have given it the thumbs up. The remake will be released "when it's done", and will feature both single- and multiplayer.
Want to know more? Take a look at this thread on the Gearbox forums, this in-game video on YouTube or the screenshots we've included below.