After weeks of speculation, Bethesda announced last night that Prey 2 is still in development, but that it won't make it out this year due to quality issues. It is unclear whether the game remains in development at Human Head Studios though, as Human Head we're quoted as exploring the possibility of doing a sequel to Rune.
The statement in full:
"Development of Prey 2 has not been cancelled but the game will not be released in 2012 as planned. The delay is due to the fact that game development has not progressed satisfactorily this past year, and the game does not currently meet our quality standards. Prey 2 has shown great promise and we regret disappointing our fans. We have made a substantial investment in game development to deliver the experience fans want. We are determined only to release the AAA game that fans rightfully expect, and are unwilling to compromise our quality standards to meet a release schedule."