No, not Skyward Sword - though we're expecting a massive push for the next Wii-based Zelda title.
No, multiple news sites have picked up on a translated report originating from french site P-Nintendo that suggests another Zelda title will debut at the show.
The bullet point, stating simply "25 years of Zelda: new zelda presented at E3!!" has obviously attracted a lot of attention. But given the exact phrasing, suggesting this is a celebration of the Zelda franchise's anniversary, it could mean a "Best Of" collection similar to the limited edition Gamecube Ocarina of Time release alongside Wind Waker, or a remake similar to Ocarina's recent 3D makeover.
Obviously take this with a pinch of salt, but it'll add some bite to the build up to Nintendo's conference next week.