In an interview with Nerdist, Deadpool-creator Rob Liefeld may have dropped a hint as to who will be the villain in Deadpool 3.
While talking about Deadpool 2, and the amazing performance by Josh Brolin, Rob says:
"Do you really hire Josh Brolin if you don't want him to play both roles?" And later on he continues by saying: "We are perfectly assembled for an X-force movie, and how do you not scratch that Stryfe-itch, right?"
In the comics, Stryfe is the main villain in "X-Cutioner's Song", a cross-over from the 90s, the X-Force/Cable crossover "Messiah War" from 2009, and "Vendetta", a Cable & X-Force/Uncanny X-Force crossover from 2014.
He is also a clone of, who else, but Cable!
Would you like to see Stryfe in a new Deadpool movie? Or are there any other villains you'd rather see?