Hideo Kojima took to Twitter to offer some gameplay advice for Metal Gear Solid V: The Phantom Pain players. This is what he had to say about his experiences when balancing the game:
"During MGSV adjustment phase in the development, I tested various types of setting & play style over and over."
"Go back to MB between main missions, take a walk, or do the silly SIDE OPS to get mind reset."
"Pls take a break time to time as this free infiltration exhausts you if playing for a long time."
Perhaps not the kind of advice you're looking for, but it does sound sensible.