It's been a poorly kept secret that The Creative Assembly (makers of the Total War series) are working on a game set in the Alien universe. Sega have yet to officially reveal the game, but if you take a look at The Creative Assembly's website. You can read the following job advert:
"We are seeking an experienced programmer with proven skills in the area of gameplay and multi-player games. The successful applicant will be working on a AAA multi-platform title on current and future generation consoles set in the Alien universe."
Sounds like this may not be a Total War style strategy game.