Legendary guitarist Carlos Santana will feature as a playable character in the upcoming Guitar Hero 5 with a live version of No One to Depend On included in the song list. Here is a quote from someone important at Red Octane with a few new Santana themed screens below:
"We're thrilled to showcase one of the top guitarists of all time in Guitar Hero 5 and offer fans the opportunity to experience Carlos Santana's signature sounds and iconic likeness first-hand," said Tim Riley, Vice President of Music Affairs for Guitar Hero. "His accomplished career and breadth of musical style are a great illustration of the variety of rock experiences we have included in the game and we are excited to announce him as the first of five playable in-game artists."