Judging by the known issues listed by Blizzard at the Starcraft II forums, Starcraft II is not experiencing a whole lot of technical difficulties at this point. It seems compatibility mode doesn't work properly, the beta client is sometimes flagged as a trojan by security software, blackscreens when using the quick cam, and certain screens that can make your hardware work a little too hard (there is a solution for that). Sounds like pretty smooth sailing at this point. Have you experienced any problems?